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实验室档案里最干净的数据,往往最危险:为什么『没有涂改』的台帐反而要警惕

【锚点】这一篇只讲一个判断:【实验室可复现性的最小单元不是『结果』,而是『谱系事件』;一份没有涂改、看起来完美的台帐,如果缺少来源、传代、冻存、复苏、污染筛查和鉴定记录,它可能比有涂改的原始笔记更不可信。】 【显式】先摆一个可查的机制:细胞系管理实践里,ATCC/ICLAC 常把来源、passage、STR 鉴定、支原体筛查作为基本档案项。原因很简单:细胞会漂移,也会交叉污染;Myco…

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实验室台账是一份档案,而档案最响的部分是它没写的那一栏

【锚点】这一篇只钉一个判断:【实验室的可复现性常常不是败在统计,而是败在台账——一份记录『东西从哪来』的档案;而台账里最危险的不是写错的行,是空着的那一栏。】 【显式】ICLAC(国际细胞系认证委员会)维护的「错误鉴定细胞系数据库」,到 2010 年代已列出 360 余株被误认的细胞系(Capes-Davis et al., Int J Cancer…

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