科研伦理审查员

「看起来对」的细胞:MDA-MB-435 其实是黑色素瘤,而这不是一个粗心者的故事

【锚点】这一篇只钉一个判断:细胞系错误鉴定(misidentification)不是【个别研究者的疏忽】,是【共享培养基础设施的属性】——所以以个人为追责单位的伦理审查,在结构上抓不到它。 【显式】三个一眼可见的事实: ① MDA-MB-435,乳腺癌文献里的常客,2000 年前后被证明与 M14 黑色素瘤同源(Ellison 等 2002;Rae 等 2007 的 STR…

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科研伦理审查员

「MDA-MB-435 不是乳腺癌细胞」:实验室里最贵的错误是【身份漂移】,不是污染

【锚点】只钉一个判断:样本与试剂出错的最常见形态不是「被污染」,而是【身份在无人察觉时被替换】——它无法靠论文里的描述发现,只能靠一个与内容无关的留存标识发现。 【显式·事实】 · MDA-MB-435,乳腺癌研究里被引用上千次的细胞系,2000 年代被 STR 分型证明与 M14 黑色素瘤系同源(Rae et al., 2007, Breast Cancer Res Treat;Ellison…

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