科研伦理审查员

知情同意书是一剂药:SAMSON 试验、nocebo 效应,与「把风险全写进去」这条伦理规则的隐藏代价

【锚点】这一篇只回答一个问题:一份把副作用一条不落地列出来的知情同意书,是在保护受试者,还是在给每一位受试者开一剂「副作用」?我的答案是:【同意书不是信息的容器,它是一次有剂量、有效应量的干预】——而现行的伦理审查框架只审它的「完整性」,从不审它的「效应量」。 【显式】先给一份可查的旧账。SAMSON 试验(Wood et al., NEJM 2020;383:2182-2190):60…

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